![]() in 1993 with an intratumorally applied liposomal formulation of immunotherapeutic DNA encoding for HLA (human leukocyte antigen)-B7. It is worth mentioning that the first clinical trial ever using in vivo gene transfer was conducted by Nabel et al. As depicted in Figure 1, such strategies aim (i) to deliver tumor-related antigen plus adjuvant to antigen presenting cells (APC) like dendritic cells (DC) that induce tumor-specific immune responses, (ii) to either deplete or reprogram tumor-induced/expanded immunoregulatory cell types, especially regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC), which collectively inhibit the induction of adaptive immune reactions in the periphery, (iii) to generate tumor-specific T cells and natural killer (NK) cells by genetic introduction of synthetic antigen receptors, termed CARs (chimeric antigen receptors), and (iv) at the tumor site itself to yield direct tumor cell killing, and to inhibit the tumor-promoting function of the tumor microenvironment (TEM). This review aims to present a comprehensive overview of the current state of nucleic acid-based anti-tumor therapeutics, and associated optimization strategies. In this regard, nucleic acid-based immunotherapeutic approaches have received growing interest. Nanotechnology-based strategies, and in particular therapeutic nucleic acids, as well as combined immunotherapies may improve the therapeutic outcome in more patients for a broad range of tumors, even in late stage. However, still only a limited number of patients respond to the already approved immunotherapies, and toxicity as well as induction of resistance towards treatment are often a problem. As a consequence of a better understanding of the tumor as a heterogeneous tissue with different types of cells, new strategies for cancer therapy have been developed, which are also applicable in combination with classical therapies. In the last 20–30 years, however, cancer treatment regimens have changed remarkably, based on the gained knowledge about molecular biology as well as tumor pathobiology and pathophysiology. ![]() Moreover, the patients often suffer from severe side-effects. ![]() The main reasons for therapy failure are chemoresistance as well as metastasis. Conventional treatments (surgery, chemotherapy, and irradiation) are often inefficient, resulting in recurrence and even death. Depending on the tumor type, stage, and location, cancer therapy can be very challenging. ![]() ![]() Aside from further improvements of individual nucleic acid-based drugs, the major perspective for successful cancer therapy will be combination treatments employing conventional regimens as well as immunotherapeutics like checkpoint inhibitors and nucleic acid-based drugs, each acting on several levels to adequately counter-act tumor immune evasion.Ĭancer is a serious and life-threatening disease with increasing incidence in today’s world. This review intends to provide a comprehensive overview of the current state of the therapeutic use of nucleic acids for cancer treatment on various levels, comprising (i) mRNA and DNA-based vaccines to be expressed by antigen presenting cells evoking sustained anti-tumor T cell responses, (ii) molecular adjuvants, (iii) strategies to inhibit/reprogram tumor-induced regulatory immune cells e.g., by RNA interference (RNAi), (iv) genetically tailored T cells and natural killer cells to directly recognize tumor antigens, and (v) killing of tumor cells, and reprograming of constituents of the tumor microenvironment by gene transfer and RNAi. Furthermore, especially in the context of the development of biocompatible, cell type targeting nano-carriers, nucleic acid-based drugs aimed to initiate and to enhance anti-tumor responses have come of age. Within the last decade, the introduction of checkpoint inhibitors proposed to boost the patients’ anti-tumor immune response has proven the efficacy of immunotherapeutic approaches for tumor therapy. ![]()
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![]() The honey bees will only fill this up once they have filled up the lower chambers, which is why this type of beehive is so popular. The upper chamber is smaller in height and is referred to as the honey supers. The boxes are added gradually as the workers fill up the existing frames with honeycomb. You won’t need to put all the boxes you purchase together all at once. The best way to work out what configuration works in your area is to visit a few local beekeepers and find out what they use. Most beekeepers have at least two brood boxes. Well, that depends on how strong your colony is and your preference. Many newbies wonder how many of these brood boxes they need for the Langstroth Hive. The Number of Brood Boxes Needed for the Langstroth Hive ![]() That’s because the lower chambers are used as the nursery of the colony, which we call the brood.īeekeepers prefer to have the larger ones as the brood chambers since they provide the colony with enough space to populate the colony as well as store enough honey to get them through the winter. The lower chambers of this hive style tend to be larger than the upper chambers. There are many variations of this type of hive that involve the stacking of boxes that form the parts of the hive. The Langstroth is a vertical hive, and expansion occurs either upward or downward. Once the Reverend figured that out, he had a type of hive that did not require the destruction of comb and the basic structure of the hive, which allowed for efficient inspections. If the space is too wide, they build more honey storage space. If the space in their beehive is too small, they seal it off with propolis. So, you’ll want to seal off those spaces and find an alternative use for them, such as advertising. If it’s too narrow, your customers will hear will complain. If the aisles are too wide, then you lose out on shelf space and limit how much product is available to the customer. The honey bees, in this case, are the proprietors. Think of the Langstroth hive as a grocery store. What makes this type of hive so effective and allows its core principles to remain in use over 100 years later is the application of bee space. They look like a narrow chest of drawers, named after their inventor, Reverend L.L. When most people talk about hives, this is what they have in mind. If you’re just getting started with beekeeping, then choosing your type of hive is one of the first tasks you must complete.īelow you will find the four beehive styles that you can choose from and their respective pros and cons. 4 Most Common Types of Beehives and Their Pros and Cons Now, let’s find out what beehive options you can provide for these enterprising tenants. So man, realizing the fatal flaw in this system, decided to find a way to keep the honey bees productive even as we raided the pantry. The fact that the bees lived through that age is a testament to the claim that they don’t need us as much as we assume they do. Imagine if you had to kill a cow to get to the milk. That’s a pretty inefficient system, but that’s all we knew. Once upon a time, when man had a hankering for honey, he would kill the colony to get at it. ![]() That’s why most beehives are made of wood even today. This is why you will find that the various types of hives try to mimic a natural situation. The beehive is where bee comfort and human convenience meet. ![]() ![]()
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![]() ![]() TikTok moderates content by first running videos through an automated system that uses computer vision to see if they might contain any content that infringes on its guidelines, which “do not allow nudity, pornography, or sexually explicit content on our platform.” Anything that is deemed suspicious is then looked at by a human moderator, but moderators are expected to look at a thousand videos in a single shift, meaning they cannot examine in detail a video’s contents.Īnd besides, Andrews said, there’s no way of knowing for sure that the people in the videos are actually flashing. “I've gotten more traffic in the past couple of days just from doing these new TikToks versus the regular trends,” she said. She quickly produced a handful of videos, which have driven traffic to her OnlyFans. Andrews came across the challenge when tipped to its existence by her TikTok manager. It’s viral gold, combining sex and the sense of getting one over on a giant tech platform with an easily replicable conceit. (BuzzFeed News will not be linking to or embedding any videos besides Andrews's, as we cannot guarantee all users taking part in the challenge are of legal age.) Even today, upon opening the app, BuzzFeed News encountered Foopah challenge videos in four of the first five videos it saw. Users encountering such content have been posting videos of their own mocking the ubiquity of boobs on their For You feeds.īuzzFeed News managed to find more than 20 Foopah challenge videos within an hour of being on the platform, only to be shown more on the For You page because of that engagement. ![]() Others show nudity in the reflection of faucets or mirrors. Some are close-up shots of someone's face, with an object in the foreground on the edge of the screen that appears to be their nipple. The videos include ones in which people flash the camera from a distance, partly obscured by a door, or peek a nipple around a corner. It’s all part of a trend called the Foopah challenge, named after the now-suspended account that initiated the flashing videos. Over the last week and a half, TikTok users have been bombarded with videos in which users expose their breasts using a variety of blink-and-you’ll-miss-it techniques that manage to get around the platform’s content moderation systems. She adjusts the strap of her top and comes into the light, fully clothed.Īnd that’s just the beginning of this sort of content on TikTok. For a split second, you can see what looks like the side profile of Andrews’s breast - though it’s difficult to discern because of the lighting. In the background, on the edge of the bath, is a collection of sex toys. In a TikTok video that’s been viewed by some 2 million people in the last 24 hours, Texas content creator Amy Andrews is standing in the shadow of her bathroom doorway. ![]() ![]() ![]() Open image overlay for Safety Canopy ® System Personal Safety System ™ with dual-stage driver and front-passenger airbags.Head Restraints - two-way manual front and rear.Open image overlay for Tire Pressure Monitoring System (TPMS) Leather-Trimmed Seats with Quilting Design and Mini-Perforation.Driver's Seat and Driver/Front Passenger Sideview Mirrors with Memory.Open image overlay for Second-Row Sliding Seats, 60/40 Split-Fold Down Second-Row Sliding Seats, 60/40 Split-Fold Down.Open image overlay for B&O ® Sound System by Bang & Olufsen ®, 10-Speakers including subwoofer B&O ® Sound System by Bang & Olufsen ®, 10-Speakers including subwoofer.Open image overlay for FordPass ® Connect with 4G LTE Wi-Fi Hotspot FordPass ® Connect with 4G LTE Wi-Fi Hotspot.Open image overlay for Wireless Apple CarPlay ® and Android Auto ™ Compatibility Wireless Apple CarPlay ® and Android Auto ™ Compatibility.SYNC ® 4 with 13.2" LCD Capacitive Touchscreen.Open image overlay for SiriusXM ® with 360L Open image overlay for Connected Built-in Navigation (with 3 years of service) Connected Built-in Navigation (with 3 years of service).Panoramic Vista Roof ® Open image overlay for Panoramic Vista Roof ®.Open image overlay for 12.3" Full Digital Instrument Cluster Open image overlay for Active Park Assist 2.0 Overhead Console with Sunglasses Storage.Powerpoints – (2) Rear – Smart Charging USB Outlets. ![]() Powerpoints – (2) First Row- (1) USB-A and (1) USB-C.Open image overlay for Rotary gear shift dial Premium-wrapped heated steering wheel with cruise and audio controls, manual tilt and telescoping steering column.Ice Blue ® Instrument Panel Cluster Lighting.Center Console with Convenient Media Bin.Sliding Sun Visor with Illuminated Vanity Mirrors (Driver and Front Passenger).Power Windows with One-Touch-Up/Down Front and Rear.Autolamp (Automatic On/Off) with Headlamp Courtesy Delay.Intelligent Access with Push-Button Start.Open image overlay for BLIS ® (Blind Spot Information System) with Cross-Traffic Alert BLIS ® (Blind Spot Information System) with Cross-Traffic Alert.Open image overlay for Rear Parking Sensors Lane-Keeping System (includes Lane-Keeping Assist, Lane-Keeping Alert and Driver Alert).Pre-Collision Assist with Automatic Emergency Braking (AEB), Pedestrian Detection, Forward Collision Warning and Dynamic Brake Support.Intelligent Adaptive Cruise Control with Stop-and-Go, Lane Centering and Speed Sign Recognition.Open image overlay for Dual-Zone Electronic Automatic Temperature Control Dual-Zone Electronic Automatic Temperature Control. ![]() ![]() Rose after that missed assignment and if it was handled differently than in past years: “Yeah, you know what. They didn’t get a lot of opportunities, but they know what they’ve got to do especially this week. On assessing receivers on Saturday: “We’ve got to do a little bit better on press. I think we’ll definitely - we have to, we have to improve.” You start to, hopefully, you’re getting better every week when you get into those situations. Partly there’s a little cliché to that, but I do think you do. The speed of the game on Saturdaywhen you’re going through camp, it just changes. There’s a lot of truth when you have new quarterbacks, I think when you have young guys. On if it’s a cliché about people getting better from week one to week two: “I think there’s a lot of truth. ![]() I think they’ll get better from week one to week two. Game gets fast out there when you get into the lights. I think that’s the best thing he settled down. On if Terry Wilson settled down when he went in second time: “He did. ![]() Defense played great, we played sloppy at times and we’ve got to get it cleaned up.” You turn the ball over four times there and it won’t be good. On if turnovers can really snowball in an environment like Florida: “Yeah, won’t be good. Had a chance to help us win more games this year, this last year.” We just kind of showed them how when we talked about it at the beginning of the year by doing the right things and taking care of the ball what you can achieve. On starting camp with a graphic tracking turnovers: “We did. Every single day starts out there, we start a period out there of ball security. You can’t throw the ball up in the air for grabs, and you’ve got to hold onto the thing and you’ve got to have great technique. That’s why we went from 130 thto 30 th and we were a top-10 for a long time. On if they can do anything extra in practice: “Every second of the day since 132 nd in the country a year and half ago has been that. That was not a good start to be in the top 10, but we’ve got a lot of games left, so we’ve got to take care of the rock.” We ended up going from 130 th to 30 th, and this year our goal was to be in the top 10. I mean, we went from 130 th in the country to 30 th (in turnovers) and we were top-10 most of the year until that Tennessee game last year when we turned it over four times. We were still up, so there was some positive from it. And they came back and after Gunnar came in in the two-minute drive, scored. “But on the positive side of that, we did (win). Can’t go anywhere and turn the ball over like that and expect to win. If you’re going to throw those, back or the corner of the end zone. Throwing the ball up in the air for grabs. We’ve still got to keep it high and tight. On if there was a theme to turnovers: “One of them got hit out by a helmet, no excuse there. Kentucky offensive coordinator Eddie Gran met with the media after practice Tuesday to discuss the Wildcats' matchup with the Florida Gators. ![]() ![]() Diagrams are used in various fields, from science and academia to business and marketing. The purpose of a diagram is to simplify complex information, highlight patterns and relationships, and communicate ideas visually. ![]() Diagrams can take many forms, such as charts, graphs, maps, or tables, and can be used to represent anything from data sets to conceptual frameworks. On the other hand, a diagram is a broader term that refers to any visual representation that conveys information or ideas. One can draw own flowchart in seconds by using RapidDraw technology. ![]() Flowcharts give to users the ability to represent structural data visually. The basic set of the stencils libraries, samples and templates allows you to draw any type of flowchart. These are commonly used in software development, project management, engineering, and other technical fields. ConceptDraw is a professional Process Flow Diagram software. ![]() The purpose of a flowchart is to visualize a process in a clear and structured way, making it easier to understand, analyze, and improve. It uses standard symbols and arrows to represent the steps in the process, along with decision points, inputs and outputs, and loops. While there is some overlap between the two, they are different in their purpose, design, and complexity.Ī flowchart is a type of diagram showing a process’s flow, from start to finish. Here is a list of our partners who offer products that we have affiliate links for.Flowcharts and diagrams are two common visual representations used to illustrate complex processes, systems, or structures. While we work hard to provide accurate and up to date information that we think you will find relevant, Forbes Advisor does not and cannot guarantee that any information provided is complete and makes no representations or warranties in connection thereto, nor to the accuracy or applicability thereof. The compensation we receive from advertisers does not influence the recommendations or advice our editorial team provides in our articles or otherwise impact any of the editorial content on Forbes Advisor. Second, we also include links to advertisers’ offers in some of our articles these “affiliate links” may generate income for our site when you click on them. This site does not include all companies or products available within the market. The compensation we receive for those placements affects how and where advertisers’ offers appear on the site. First, we provide paid placements to advertisers to present their offers. This compensation comes from two main sources. To help support our reporting work, and to continue our ability to provide this content for free to our readers, we receive compensation from the companies that advertise on the Forbes Advisor site. The Forbes Advisor editorial team is independent and objective. Because project plan templates can also create a road map, the template can also help identify holes in the project plan. Project plan templates provide you with the technology you need, offer prompts for the key information and create reminders and deadline alerts. This is where project plan templates come in. Additionally, project plans can also help project managers stay organized because they can easily track progress of the multiple projects they are overseeing.Ī project plan is meant to help with project management, but sometimes the process of creating a project plan can seem daunting. A project plan helps keep the team organized and on track. With a detailed project plan, however, each step of the process is broken down into management phases and steps so the entire project feels more manageable. ![]() When this happens, projects struggle to get off the ground or they stagnate. When working on a long-term, significant or cross-functional project, it can be easy to become overwhelmed by the number of moving pieces and steps involved in the project. Because team members and other stakeholders can see each task and phase in the project and the responsible party, a project plan increases transparency and fosters accountability. Fosters transparency and accountability.Project plans that include budgeting features can also alert team members to budget concerns early on so corrections can be made before things get too far off track. Other team members can adjust their workflow accordingly. Because each step of the project is documented, the project plan can notify team members of any delays as soon as possible. Notifies team members of delays or budget challenges.Because the entire team can see the tasks, assignments, deadlines and other important information for the project, the project plan streamlines communication among the team members. Project plans have several benefits, including: On ClickUp's Website Benefits of Creating a Project Plan ![]() ![]() ![]() ![]() Click Data Source database or cloud app and select one QuickBooks connection as source from the drop-down list.Select the Use new runtime checkbox to activate the Nested Objects option.Please note that if you omit this step, the package name will remain Untitled in the list of created packages In the open package editor, rename your package by clicking and editing the package name.Follow these simple steps to adjust general package settings: To successfully create and run a new package, you need to adjust general package settings and configure task editor settings. Creating Package for Importing into QuickBooks Read the QuickBooks topic to find out how to configure settings of the necessary cloud app and check the Connections topic to know how to create a connection following several simple steps. One connection will serve as source, another one - as target. Creating Connectionsįirst, you need to create connections in Skyvia, which you will use as source and target in your import package.Īs we are going to import Invoices and Customers between two different QuickBooks accounts, we create two connections to two QuickBooks accounts. Make sure you have selected the Use new runtime checkbox in your import package before adding a task. Please note that the Nested Objects functionality is available when the new data integration runtime is selected. To find out how to create an import package to import customers and invoices into QuickBooks Online and configure mapping settings of nested objects correctly, read our step-by-step instruction below. However, when you select the Nested Objects checkbox in your import package, the nested Line object is divided into separate fields, and it becomes possible to use Expression or Constant, then map necessary columns easily and import data with changes made. The main problem of importing the Invoce object is that its Line column is not represented as separate fields, it has an array data structure, and if during transfer of invoices from one QuickBooks company to another, you need to make changes to the quantity of goods for each invoice for example, you should specify it somehow inside json strings, which is quite inconvenient and problematic. If the Customer object is simple for import, the Invoice object is not so easy in mapping. In this tutorial, we will show how to import Customers and Invoices from one QuickBooks account to another one. Easy Importing Invoices and Customers Between QuickBooks Online Accounts ![]() ![]() Your expected start date will be shown on the confirmation page after you place an order. In most areas, new orders begin within 2 to 3 days after the order request has been received. The lead time to start delivery on a new order varies by area. When will Lincoln Journal Star home delivery start? You can expect responsive customer service that allows you to review and update your delivery and billing information, stop delivery of your newspaper when you're away, discover special promotions and notify the newspaper of any comments or questions you have. What should I expect from Lincoln Journal Star Customer Service? Your credit card will be charged for the amount of the subscription. Simply enter your credit card information on our secure checkout page. You can charge your Lincoln Journal Star subscription on most major credit cards, such as MasterCard and Visa, although acceptance of American Express and Discover varies by newspaper. Can I pay by credit card for my Lincoln Journal Star subscription? See our privacy policy for more details about the use of all information that you provide. All sensitive information such as credit cards or personal information is securely encrypted for transmission. The personal information we receive from you is used only to provide the highest quality home delivery service available. A Lincoln Journal Star subscription customer service representative can help determine what delivery options are available if your address doesn’t qualify for Lincoln Journal Star home delivery. Lincoln Journal Star discount subscriptions are not available for every address. Can I still subscribe if my address doesn't qualify for home delivery? Additionally, if your delivery address is a PO Box number, the newspaper cannot deliver to your address. This situation occurs mainly in very rural areas. Please note that while newspaper subscription prices are published for your zip code there is a very small chance that your specific address is not serviced by the Lincoln Journal Star. If home delivery is available in your area, Lincoln Journal Star subscription rates will populate on the results page. Navigate to the search box at the bottom of this page and enter your home delivery zip code. The following March, GateHouse Media announced that it had submitted the winning bid of $380 million for the six dailies in Illinois and Ohio.Where can I check to see if Lincoln Journal Star home delivery is available in my area? In November of 2006, Copley Press CEO David Copley announced he was selling the entire group of Copley newspapers except for the flagship, the San Diego Union-Tribune. But a few years later, Copley sold the so-called Fox Valley group of dailies in suburban Chicago, Joliet, Aurora, Elgin and Waukegan, leaving just its downstate dailies in Peoria, Galesburg, Springfield and Lincoln. The Peoria-Galesburg purchase took it to eight daily newspapers in Illinois. The only way out was to sell the company.Ĭopley was a family-owned group launched from Aurora, Ill., in the 1920s. Each time, the company had to borrow money to buy back the stock of the departing employees, putting a greater debt load onto the company. to The Copley Press Inc., of LaJolla, Calif.Īt the time, the stock ownership plan was so successful that employees were retiring years ahead of actuarial projections. The newspaper's employee-owners voted in July 1996 to dissolve the stock ownership plan and sell all the stock of Peoria Journal Star Inc. The bulk of those first 150 years were covered by Bill Adams, Peoria's ''Mr. The newspaper marked its 150th anniversary in 2005. which is owned by GateHouse Media, a publicly-traded company based in New York outside Rochester. The Journal Star is owned by Peoria Journal Star Inc. ![]() |